AHK_Cu

AHK-Cu — Synthetic Copper Tripeptide for Hair Research

AHK-Cu (Alanine-Histidine-Lysine copper complex) is a synthetic copper-binding tripeptide designed specifically for hair follicle and dermal biology research. While structurally related to the naturally occurring GHK-Cu, AHK-Cu is an entirely synthetic peptide with distinct receptor binding characteristics and enhanced specificity for dermal papilla cell activation and hair growth cycle modulation.

Mechanism of Action

AHK-Cu stimulates dermal papilla cell (DPC) proliferation and promotes the transition from telogen (resting phase) to anagen (growth phase) in hair follicle cycling. Research demonstrates its ability to upregulate VEGF expression in dermal papilla cells, enhance ECM signaling through integrin pathways, and modulate Wnt/β-catenin signaling — a critical pathway in hair follicle morphogenesis and regeneration. The copper ion component serves as a cofactor for lysyl oxidase and other matrix-remodeling enzymes.

Research Applications

• Hair follicle biology and growth cycle modulation
• Dermal papilla cell proliferation studies
• Wnt/β-catenin signaling in follicle regeneration
• Comparative studies with GHK-Cu and other copper peptides
• VEGF expression and follicular angiogenesis
• Scalp tissue biology and ECM remodeling

Product Specifications

• Quantity: 100mg per vial or 50mg depending on size selected.
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: Refrigerate once reconstituted
• Testing: USA lab tested, COA available

Not for human use or consumption. For research use only.