PT-141 — Melanocortin Receptor Agonist Peptide
PT-141 is a synthetic cyclic heptapeptide derived from the melanocortin peptide Melanotan II (MT-2). Unlike its parent compound, PT-141 was specifically developed for its selective activity on melanocortin receptors MC3R and MC4R in the central nervous system, making it a unique research tool for studying melanocortin-mediated physiological pathways.
Mechanism of Action
PT-141 acts as a non-selective melanocortin receptor agonist with preferential binding to MC3R and MC4R subtypes located in the hypothalamus and limbic system. Its mechanism of action is distinct from PDE5 inhibitors in that it operates through central nervous system pathways rather than peripheral vascular mechanisms. This central-acting profile makes PT-141 valuable for research investigating the neural basis of melanocortin signaling.
Research Applications
- Melanocortin receptor signaling (MC3R/MC4R) studies
- Central nervous system pathway activation research
- Hypothalamic-pituitary axis modulation
- Appetite regulation and energy homeostasis
- Comparative studies with other melanocortin agonists
Product Specifications
- Quantity: 10mg per vial
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: Refrigerate after reconstitution
- Testing: USA lab tested, COA available
For research purposes only. Not for human use or consumption.
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