IGF1-LR3

IGF1-LR3 — Long Arginine Insulin-Like Growth Factor

IGF1-LR3 (Long Arginine 3 IGF-1) is an 83-amino acid synthetic analog of insulin-like growth factor 1, featuring a 13-amino acid N-terminal extension and an arginine substitution at position 3. These modifications dramatically reduce binding to IGF binding proteins (IGFBPs), resulting in a compound with approximately 2-3x the potency and significantly longer functional half-life compared to native IGF-1.

Mechanism of Action

IGF1-LR3 binds to the IGF-1 receptor (IGF-1R), a transmembrane tyrosine kinase receptor that activates both the PI3K/Akt/mTOR pathway (promoting protein synthesis and cell survival) and the Ras/MAPK pathway (promoting cell proliferation and differentiation). Because LR3 has minimal affinity for IGFBPs, a greater proportion of the peptide remains bioactive in circulation, providing enhanced and prolonged receptor stimulation compared to recombinant human IGF-1.

Research Applications

• IGF-1R signaling and mTOR pathway activation
• Muscle protein synthesis and hypertrophy research
• Cell proliferation and differentiation studies
• IGFBP interaction and bioavailability research
• Neuroprotective and neurogenesis investigations

Product Specifications

• Quantity: 1mg per vial
• Purity: ≥98% (HPLC verified)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution
• Testing: USA lab tested, COA available

For research purposes only. Not for human use or consumption.